Formal Study NameA Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix (PROSPECT)
Primary Principal InvestigatorDwight Rouse
Additional Principal InvestigatorBrenna Hughes
A randomized trial of 600 women evaluating the use of micronized vaginal progesterone or pessary versus control (placebo) to prevent early preterm birth in women carrying twins and with a cervical length of less than 30 millimeters.
Studies show women carrying twins are more likely to deliver prior to 37 weeks compared to women carrying one baby. Women with a shortened cervix are more likely to deliver earlier than women with a normal cervical length. Women are offered randomization to:
- Progesterone suppositories - shown to be effective in singletons with a shortened cervix.
- Placebo - identical looking medication with no active ingredients.
- Pessary - a round silicone device that covers the cervix and provides additional support.
See study details at ClinicalTrials.gov.
Pregnant with twins and shortened cervix prior to 24 weeks.
Patients receive $20 for the randomization visit to compensate for time and travel and an additional $10 at each monthly study visit. Upon delivery patients receive a case of newborn diapers.
Women & Infants
Maternal Fetal Medicine