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The Division of Urogynecology has many active research studies for pelvic floor disorders, including urinary incontinence, pelvic organ prolapse, and bowel incontinence.
The division is fortunate to be part of the the Pelvic Floor Disorders Network (PFDN) which includes seven research sites across the US, supported by the National Institute of Child Health and Human Development.

Active Studies

Mid-Urethral Sing vs Botox A ® (MUSA) compares treatment with either injections of Botulinum toxin A (Botox A ®) in the muscle surrounding the bladder OR mid-urethral sling placement in the operating room for the treatment of mixed urinary incontinence. Mixed urinary incontinence includes both stress incontinence (leakage with cough, sneeze, activities) and urge incontinence (incontinence with urgency). Women who choose to participate in the MUSA trial will be randomized (like flipping a coin) to receive either Botox A ® or mid-urethral sling and will be followed for a 6 month period

Randomized trial of Retropubic versus Single-incision Mid-Urethral Sling (Altis™) for Concomitant Management of Stress urinary incontinence during Native Tissue Vaginal Repair (ALTIS). This trial evaluates use of the Altis ™ sling in improving irritative voiding symptoms/voiding dysfunction when combined with prolapse surgery. Women are followed for a 12 month period.

An Evaluation of the Vesair® Bladder Control System for the Treatment of Stress Urinary Incontinence in Post-Menopausal Women, Vesair Pivotal Trial (VAPOR) sponsored by Solace Therapeutics, Inc. evaluates the use of a non-surgical balloon device on women who have stress urinary incontinence and for whom other treatments have been ineffective.

Optimization of spontaneous trial of void (OPTION): a prospective cohort study. This trial evaluates voiding problems after surgery by teaching self catheterization, in an effort to avoid the need for an indwelling catheter.

Intravesical Lidocaine versus Oral Phenazopyridine for Bladder OnabotulinumtoxinA Analgesia: (OPIL)
This trial evaluates whether patients who undergo bladder Botox A ® have greater comfort with the procedure when their bladder is numbed with lidocaine given into the bladder through a catheter versus taking a medication, phenazopyridine, before the procedure by mouth.

Contact information

Ann Meers, BS, RN, CCRC, Research Supervisor
ameers@wihri.org

Division of Urogynecology and Reconstructive Pelvic Surgery
101 Plain Street
Providence, RI
(401) 430-8228