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Woman And Infants
Woman And Infants

Fetal and Infant Response to SRI Treatment (FIRST)

Organizations Women & Infants
Research Type Clinical
Therapeutic Area of Study Depression
Principal Investigators
Eligibility Criteria Participants must be pregnant women between the ages of 18-40.  We are looking for women who have never experienced depression as well as those that currently have depression and/or are taking antidepressant medications.
Recruitment Status Open
Date Recruitment Ends 01/31/2013
Date Study Started 02/01/2008
Date Study Ends 01/31/2013
Contact Information For more information call (401) 274-1122, ext. 8954 or email fetalstudy@wihri.org
Description Each year at least 600,000 pregnant women suffer from Major Depressive Disorder (MDD) during pregnancy. Many women face the dilemma of whether or not to treat their depression with medication. Recent studies suggest that fetal exposure to either maternal MDD or antidepressant medication may be associated with adverse symptoms in the infant shortly after birth.

Nearly 40% of depressed pregnant women are choosing treatment with antidepressant medication. This study examines the effects of maternal depression and maternal antidepressant use on fetal and newborn behavior and neurobehavioral development.

We will examine fetal neurobehavior at 28 and 34 weeks gestation using ultrasound observation and fetal heart rate monitoring. After delivery, we observe the infants’ motor patterns, reflexes, behavior, sleep, and attention during their first month.
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Woman And Infants
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