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Woman And Infants

Press Release

Researchers study protein level-ovarian cancer link
11/20/2012

Researchers with the Center for Biomarkers and Emerging Technologies (CBET) at Women & Infants Hospital of Rhode Island are credited with developing algorithms marketed world-wide that can analyze blood protein levels in women as predictors that a pelvic mass is or is not ovarian cancer.

Now, the work is advancing one step further to determine if the level of one of those proteins fluctuates during a woman's normal menstrual cycle. This information will help them further diagnose a mass as ovarian or endometrial cancer.

"The purpose of this study is to determine if levels of the protein HE4 vary during menstrual cycles in ovulatory women," explained Lynae Brayboy, MD, principal investigator on the study. "HE4 is a sensitive seriological marker that is elevated in certain ovarian and endometrial cancer. In order to optimize our use of HE4 as a tumor marker, we need to characterize its expression in the normal menstrual cycle."

The study, being coordinated with the hospital's Center for Reproduction and Infertility, is seeking women ages 18 to 45 who are having regular periods and are not taking birth control pills. Study participants will have blood and urine samples taken at four different visits and be asked to use a urinary ovulation predictor kit to time their visits. They will be compensated with $10 gift cards at each visit and $60 in gift cards at the end of their participation.

For more information, call (401) 274-1122, ext. 8422, or email lbrayboy@wihri.org or Lynae_Brayboy@Brown.edu.

About Women & Infants Hospital

Women & Infants Hospital of Rhode Island, a Care New England hospital, is one of the nation's leading specialty hospitals for women and newborns. The primary teaching affiliate of The Warren Alpert Medical School of Brown University for obstetrics, gynecology and newborn pediatrics, as well as a number of specialized programs in women's medicine, Women & Infants is the eighth largest stand-alone obstetrical service in the country with nearly 8,400 deliveries per year. In 2009, Women & Infants opened the country's largest, single-family room neonatal intensive care unit.

New England's premier hospital for women and newborns, Women & Infants and Brown offer fellowship programs in gynecologic oncology, maternal-fetal medicine, urogynecology and reconstructive pelvic surgery, neonatal-perinatal medicine, pediatric and perinatal pathology, gynecologic pathology and cytopathology, and reproductive endocrinology and infertility. It is home to the nation's only mother-baby perinatal psychiatric partial hospital, as well as the nation's only fellowship program in obstetric medicine.

Women & Infants has been designated as a Breast Center of Excellence from the American College of Radiography; a Center for In Vitro Maturation Excellence by SAGE In Vitro Fertilization; a Center of Biomedical Research Excellence by the National Institutes of Health; and a Neonatal Resource Services Center of Excellence. It is one of the largest and most prestigious research facilities in high risk and normal obstetrics, gynecology and newborn pediatrics in the nation, and is a member of the National Cancer Institute's Gynecologic Oncology Group and the National Institutes of Health's Pelvic Floor Disorders Network.

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